Scientific Evidence

Every session in Entrainium is grounded in peer-reviewed research. Explore the clinical studies supporting our therapeutic protocols.

Presets

50+

Studies

📚 Foundation of Brainwave Entrainment

Auditory beat stimulation has been studied across multiple domains. These systematic reviews and meta-analyses provide the scientific foundation for all therapeutic presets.

Ingendoh, R. M., Posny, E. S., & Heine, A. (2023). Binaural beats to entrain the brain? A systematic review of the effects of binaural beat stimulation on brain oscillatory activity. PLoS ONE, 18(5), e0286023. Strong Read Study

Garcia-Argibay, M., Santed, M. A., & Reales, J. M. (2019). Efficacy of binaural auditory beats in cognition, anxiety, and pain perception: a meta-analysis. Psychological Research, 83(2), 357–372. Strong Read Study

Chaieb, L., Wilpert, E. C., Reber, T. P., & Fell, J. (2015). Auditory beat stimulation and its effects on cognition and mood states. Frontiers in Psychiatry, 6, 70. Strong Read Study

🧠 Pure Brainwave Bands

Research supporting our Delta, Theta, Alpha, Beta, and Gamma pure frequency presets.

Delta (2 Hz) – Deep Sleep & Healing

Abeln, V., Kleinert, J., Strüder, H. K., & Schneider, S. (2014). Brainwave entrainment for better sleep and post-sleep state: A pilot study. The Journal of Sports Medicine and Physical Fitness, 54(5), 653–660. Moderate Read Study

Theta (6 Hz) – Meditation & Creativity

Jirakittayakorn, N., & Wongsawat, Y. (2017). Brain responses to a 6-Hz binaural beat: Effects on general theta rhythm and frontal midline theta activity. Frontiers in Neuroscience, 11, 365. Strong Read Study

Reedijk, S. A., Bolders, A., & Hommel, B. (2013). The impact of binaural beats on creativity. Frontiers in Human Neuroscience, 7, 786. Moderate Read Study

Alpha (10 Hz) – Relaxed Awareness

Wahbeh, H., Calabrese, C., & Zwickey, H. (2007). Binaural beat technology in humans: A pilot study to assess psychologic and physiologic effects. The Journal of Alternative and Complementary Medicine, 13(1), 25–32. Moderate Read Study

Beta (20 Hz) – Active Thinking

Lane, J. D., Kasian, S. J., Owens, J. E., & Marsh, G. R. (1998). Binaural auditory beats affect vigilance performance and mood. Physiology & Behavior, 63(2), 249–252. Moderate Read Study

Gamma (40 Hz) – Peak Cognition

Beauchene, C., Abaid, N., Moran, R., Diana, R. A., & Leonessa, A. (2016). The effect of binaural beats on visuospatial working memory and cortical connectivity. PLoS ONE, 11(11), e0166630. Strong Read Study

Iaccarino, H. F., et al. (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature, 540(7632), 230–235. Strong Read Study

💊 Therapeutic Sessions

Clinical evidence for condition-specific protocols including sleep, anxiety, pain, and cognitive support.

Sleep Protocols (Insomnia & Deep Sleep)

Jirakittayakorn, N., & Wongsawat, Y. (2018). A novel insight of effects of a 3-Hz binaural beat on sleep stages during sleep. Frontiers in Human Neuroscience, 12, 387. Strong Read Study

Bavafa, A., Khoshraftar Yazdi, N., Hojjat, S. K., et al. (2023). The effectiveness of theta binaural beats for improving sleep quality in women with primary insomnia. Complementary Therapies in Clinical Practice, 53, 101793. Moderate Read Study

Anxiety Relief

Padmanabhan, R., Hildreth, A. J., & Laws, D. (2005). A prospective, randomized, controlled study examining binaural beat audio and pre-operative anxiety in patients undergoing general anaesthesia for day case surgery. Anaesthesia, 60(9), 874–877. Strong Read Study

Santamaria, D., Kim, H., & Song, H. S. (2024). Effect of binaural beats on anxiety and blood pressure: A systematic review and meta-analysis. Applied Sciences, 14(13), 5675. Strong Read Study

Pain Management

Zampi, D. D. (2016). Efficacy of theta binaural beats for the treatment of chronic pain. Alternative Therapies in Health and Medicine, 22(Suppl 1), 32–38. Preliminary Read Study

ADHD Focus Support

Kennel, S., Taylor, A. G., Lyon, D., & Bourguignon, C. (2010). Pilot feasibility study of binaural auditory beats for reducing symptoms of inattention in children and adolescents with attention-deficit/hyperactivity disorder. Journal of Pediatric Nursing, 25(1), 3–11. Preliminary Read Study

Deep Meditation

Lavallee, C. F., Koren, S. A., & Persinger, M. A. (2011). A quantitative electroencephalographic study of meditation and binaural beat entrainment. Journal of Alternative and Complementary Medicine, 17(4), 351–355. Moderate Read Study

Focus SMR (Sensorimotor Rhythm)

Egner, T., & Gruzelier, J. H. (2004). EEG biofeedback of low beta band components: Frequency-specific effects on variables of attention and event-related brain potentials. Clinical Neurophysiology, 115(1), 131–139. Strong Read Study

🔬 Advanced Protocols

Multi-stage therapeutic journeys supported by research on complex interventions.

Circadian Reset

Kaplan, K. A., Hirshman, J., Hernandez, B., et al. (2017). When a gold standard isn't so golden: Lack of prediction of subjective sleep quality from sleep polysomnography. Biological Psychology, 123, 37–46. Moderate Read Study

Lucid Dreaming Protocol

Voss, U., Holzmann, R., Hobson, A., et al. (2014). Induction of self awareness in dreams through frontal low current stimulation of gamma activity. Nature Neuroscience, 17(6), 810–812. Strong Read Study

Immune Modulation

Thayer, J. F., & Sternberg, E. M. (2010). Neural aspects of immunomodulation: Focus on the vagus nerve. Brain, Behavior, and Immunity, 24(8), 1223–1228. Strong Read Study

🔮 Solfeggio Frequencies

Ancient healing tones with emerging scientific interest. Evidence is preliminary but promising.

528 Hz – DNA Repair & Love Frequency

Akimoto, K., Hu, A., Yamaguchi, T., & Kobayashi, H. (2018). Effect of 528 Hz music on the endocrine system and autonomic nervous system. Health, 10(9), 1159–1170. Preliminary Read Study

Babayi Daylari, T., Riahi, S. M., Dolatabadi, N. K., et al. (2021). The effects of 528 Hz sound wave to reduce cell death in human astrocyte primary cell culture treated with ethanol. Journal of Addiction Medicine, 15(6), 468–473. Preliminary Read Study

432 Hz – Verdi Natural Tuning

Calamassi, D., & Pomponi, G. P. (2019). Music tuned to 432 Hz versus music tuned to 440 Hz for improving sleep in patients with spinal cord injuries: A double-blind cross-over pilot study. Acta Medica Mediterranea, 35, 3057–3062. Preliminary Read Study

📌 Note on Solfeggio Research

While Solfeggio frequencies have ancient roots and contemporary popularity, scientific evidence remains limited. The studies above represent the beginning of formal research. Most effects are based on traditional use, subjective reports, and small-scale observations. Use with mindful awareness and realistic expectations.

🌍 Schumann Resonances

Earth's natural electromagnetic frequencies. Research explores potential biological synchronization.

7.83 Hz – Fundamental Earth Resonance

Persinger, M. A. (2014). Schumann resonance frequencies found within quantitative electroencephalographic activity: Implications for earth-brain interactions. International Letters of Chemistry, Physics and Astronomy, 30, 24–32. Theoretical Read Study

König, H. L. (1974). ELF and VLF signal properties: Physical characteristics. In M. A. Persinger (Ed.), ELF and VLF Electromagnetic Field Effects (pp. 9–34). Springer. Theoretical

🌐 Understanding Schumann Resonances

Schumann resonances are real, measurable electromagnetic frequencies in Earth's atmosphere. However, their direct therapeutic effects through audio entrainment remain speculative. Research suggests potential biological connections, but clinical evidence is limited. These presets are inspired by planetary rhythms and may support grounding and balance.

⚠️ Important Medical Disclaimer

Not Medical Treatment: Entrainium is for wellness and educational purposes only. It is not intended to diagnose, treat, cure, or prevent any medical condition.
Individual Variation: Responses to brainwave entrainment vary significantly. Scientific evidence is mixed, and many studies have small sample sizes or methodological limitations.
Consult Healthcare Professionals: If you have epilepsy, seizure disorders, psychiatric conditions, or any medical concerns, consult a qualified healthcare professional before use.
Safety First: Never use while driving, operating machinery, or performing tasks requiring full attention. Start with low volumes and discontinue if you experience discomfort.
Evidence Levels: We transparently label evidence quality. Strong = multiple rigorous studies, Moderate = several smaller studies, Preliminary = limited research, Theoretical = conceptual frameworks.